1. a change or variation occurring in the course of something.
2. interchange or alternation, as of states or things.
3. vicissitudes, successive, alternating, or changing phases or conditions,
as of life or fortune; ups and downs.
4. regular change or succession of one state or thing to another.
5. change; mutation; mutability
Usage
He remained steadfast through the vicissitudes of life.
vi.cis.si.tude
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